ITPR3 antibody (AA 21-120)

Catalog No. ABIN1387432

This Rabbit Polyclonal antibody specifically detects ITPR3 in ELISA, WB, IF (p), IF (cc), IHC (p) and IHC (fro). It exhibits reactivity toward Mouse.It has been mentioned in 1 publication

Quick Overview for ITPR3 antibody (AA 21-120) (ABIN1387432)

Target: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITPR3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ITPR3 Antibody

Binding Specificity: AA 21-120

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ITPR3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-ITPR3 antibody (ABIN1387432)

Velázquez, Enos, Carson, Cranford, Bader, Sougiannis, Pritchett, Fan, Carson, Murphy: "miR155 deficiency aggravates high-fat diet-induced adipose tissue fibrosis in male mice." in: Physiological reports, Vol. 5, Issue 18, (2018) (PubMed).

Target Details for ITPR3

Target: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Alternative Name: Itpr3

Background:

Synonyms: IP3R-III, IP3 receptor isoform 3, 4 antibody 5-trisphosphate receptor, 5-trisphosphate receptor type 3, FLJ36205, Inositol 1, Inositol 1,4,5 trisphosphate receptor type 3, IP3 receptor, IP3R 3, IP3R, IP3R3, ITPR 3, ITPR3, ITPR3_HUMAN, Type 3 inositol 1, Type 3 inositol 1,4,5 trisphosphate receptor, Type 3 InsP3 receptor.

Background: Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.

Gene ID: 3710

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, BCR Signaling