ITPR3 antibody (AA 21-120) (Biotin)

Catalog No. ABIN1397481

The Biotin-conjugated Rabbit Polyclonal anti-ITPR3 antibody (ABIN1397481) specifically detects ITPR3 in ELISA, WB, IHC (p) and IHC (fro). The antibody is reactive with Mouse samples.

Quick Overview for ITPR3 antibody (AA 21-120) (Biotin) (ABIN1397481)

Target: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITPR3 antibody is conjugated to Biotin

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ITPR3 Antibody (Biotin)

Binding Specificity: AA 21-120

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ITPR3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ITPR3

Target: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Alternative Name: Itpr3

Background:

Synonyms: IP3R-III, IP3 receptor isoform 3, 4 antibody 5-trisphosphate receptor, 5-trisphosphate receptor type 3, FLJ36205, Inositol 1, Inositol 1,4,5 trisphosphate receptor type 3, IP3 receptor, IP3R 3, IP3R, IP3R3, ITPR 3, ITPR3, ITPR3_HUMAN, Type 3 inositol 1, Type 3 inositol 1,4,5 trisphosphate receptor, Type 3 InsP3 receptor.

Background: Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.

Gene ID: 3710

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, BCR Signaling