ANT1+ANT2+ANT3+ANT4 antibody

Catalog No. ABIN1387829

Product Details

Target: ANT1+ANT2+ANT3+ANT4

Reactivity: Mouse, Rat, Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ANT1/2/3/4

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details

Target: ANT1+ANT2+ANT3+ANT4

Background:

Synonyms: ATP carrier protein 1, ADP ATP carrier protein heart/skeletal muscle isoform T1, ADP/ATP translocase 1, ADT1_HUMAN, ANT 1, ANT, ANT1, ATP carrier protein 2, ADP ATP carrier protein heart/skeletal muscle isoform T2, ADP/ATP translocase 2, ADT2_HUMAN, ANT 2, ANT, ATP carrier protein 3, ADP ATP carrier protein heart/skeletal muscle isoform T3, ADP/ATP translocase 3, ADT3_HUMAN, ANT3, ATP carrier protein 4, ADP ATP carrier protein heart/skeletal muscle isoform T4, ADP/ATP translocase 4, ADT4_HUMAN, ANT 4,ANT4.

Background: Adenine nucleotide translocator (ANT) and the voltage-dependent anion-selective channel proteins 1 and 2 (VDAC1 and VDAC2) are components of the permeability transition pore complex (PTPC) of the mitochondrial inner and outer membranes, respectively. Formation of PTPCs, the subsequent dissipation of mitochondrial inner membrane potential and release of cytochrome c through the outer mitochondrial membrane are critical events in the early stages of apoptosis. Bax, a proapoptotic protein, has been shown to act upon ANT to induce the dissipation of mitochondrial inner membrane potential. ANT1 has a role in the maintenance of mitochondrial DNA by catalyzing the exchange of ADP and ATP across the mitochondrial inner membrane.