RAB11A antibody (FITC)

Catalog No. ABIN1390208

The Rabbit Polyclonal anti-RAB11A antibody is suitable to detect RAB11A in samples from Human. It has been validated for WB and IF.

Quick Overview for RAB11A antibody (FITC) (ABIN1390208)

Target: RAB11A (RAB11A, Member RAS Oncogene Family (RAB11A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB11A antibody is conjugated to FITC

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-RAB11A Antibody (FITC)

Purpose: Rab11A Polyclonal Antibody, FITC Conjugated

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Rab11A

Isotype: IgG

Application Details

Application Notes: WB(1:500-2000), IF(1:100-500)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RAB11A

Target: RAB11A (RAB11A, Member RAS Oncogene Family (RAB11A))

Alternative Name: Rab11a

Background:

Synonyms: Rab 11, Rab11A, Rab-11A, RAB 11A member oncogene family, Rab-11, RAB11 A, RAB11, RAB11A, RAB11A member RAS oncogene family, Ras related protein Rab 11A, Ras related protein Rab11A, Ras-related protein Rab-11A, RB11A_HUMAN, YL 8, YL8, MGC1490.

Background: Rab11a, Rab11b and Rab25 are members of the Rab11 family of small Ras-like GTPases. Rab11 (isoforms Rab11a and Rab11b) functions as a key regulator in the recycling of perinuclear, plasma membrane and Golgi compartment endosomes (1,2). Despite some overlap, distinct differences exist between Rab11a and Rab11b in both their cellular distribution and functional roles. Rab11a is ubiquitously expressed while Rab11b is found mainly in the heart and brain (3,4). Like other Rab proteins, Rab11 exerts its function via interactions with Rab11 family interacting proteins (FIPs). While there are three distinct classes of FIPs, all appear to share a conserved carboxy-terminal Rab-binding domain that allows Rab-FIP protein interaction. When bound together, these proteins are thought to regulate membrane-associated protein sorting (5,6).

Pathways: Regulation of Cell Size, Thromboxane A2 Receptor Signaling, Regulation of long-term Neuronal Synaptic Plasticity