SYT11 antibody (AA 51-100) (Alexa Fluor 350)

Catalog No. ABIN1391043

Product Details anti-SYT11 Antibody (Alexa Fluor 350)

Target: SYT11 (Synaptotagmin XI (SYT11))

Binding Specificity: AA 51-100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYT11 antibody is conjugated to Alexa Fluor 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Synaptotagmin XI

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SYT11

Target: SYT11 (Synaptotagmin XI (SYT11))

Alternative Name: Synaptotagmin 11 (SYT11 Products)

Synonyms: SYT12 antibody, sytXI antibody, 1500004A13Rik antibody, 3632445O20Rik antibody, 5430404N14Rik antibody, 6530420C11Rik antibody, AI851970 antibody, syt11 antibody, fc52d10 antibody, fi68d01 antibody, zgc:55556 antibody, wu:fc52d10 antibody, wu:fi68d01 antibody, SYT11 antibody, DKFZp459M023 antibody, synaptotagmin 11 antibody, synaptotagmin XI antibody, synaptotagmin XIa antibody, synaptotagmin XIb antibody, SYT11 antibody, Syt11 antibody, syt11a antibody, syt11 antibody, syt11b antibody

Background:

Synonyms: Synaptotagmin 11, Synaptotagmin 12, Synaptotagmin XI, Synaptotagmin-11, synaptotagmin XII, synaptotagmin-XII, Synaptotagmin11, Synaptotagmin12, Synaptotagmin-11, Synaptotagmin-12, SynaptotagminXI, SYT 11, SYT 12, SYT-11, SYT-12, Syt XI, Syt11, SYT11_HUMAN, SYT12, SytXI, DKFZp781D015, KIAA0080, MGC10881, MGC17226.

Background: Synaptotagmins are a large family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Synaptotagmin XI, also known as SYT11 (Synaptotagmin-11), is a 431 amino acid protein that localizes to the membrane and is expressed ubiquitously with highest expression in brain and lung. Like other Synaptotagmin proteins, Synaptotagmin XI is involved in the calcium-dependent exocytosis of secretory vesicles and is thought to act as a calcium sensor during vesicular trafficking. Synaptotagmin XI contains two C2 domains through which it can bind either three calcium ions or the zinc-finger protein Parkin (a juvenile Parkinson?s disease gene product), the latter of which causes the polyubiquitination and subsequent degradation of Synaptotagmin XI by the proteasome complex. Defects in the gene encoding Synaptotagmin XI are implicated in a number of neurological disorders, including schizophrenia and Parkinson?s disease.

Gene ID: 23208