TOR1B antibody (AA 281-336) (Alexa Fluor 350)

Catalog No. ABIN1391577

Product Details anti-TOR1B Antibody (Alexa Fluor 350)

Target: TOR1B (Torsin Family 1, Member B (Torsin B) (TOR1B))

Binding Specificity: AA 281-336

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOR1B antibody is conjugated to Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Torsin B

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TOR1B

Target: TOR1B (Torsin Family 1, Member B (Torsin B) (TOR1B))

Abstract: TOR1B Products

Synonyms: MGC82811 antibody, tor1a antibody, 2610016F05Rik antibody, DQ1 antibody, torsinB antibody, torsin family 1, member B (torsin B) L homeolog antibody, torsin family 1, member B (torsin B) antibody, torsin family 1 member B antibody, torsin family 1, member B antibody, tor1b.L antibody, tor1b antibody, TOR1B antibody, Tor1b antibody

Background:

Synonyms: DQ1, Tor1b, Torsin 1B, TOR1B, FKSG18, Torsin family 1 member B, TOR1B_HUMAN.

Background: TorsinB is a 336 amino acid protein that localizes to the lumen of endoplasmic reticulum and belongs to the Torsin family. Expressed in a variety of tissues with particularly high levels in adult brain, TorsinB is thought to function as a molecular chaperone that assists in the conformational folding of membrane and secreted proteins. Via its ability to regulate protein folding, TorsinB plays a key role in postnatal developmental events and is essential for proper neurological development. TorsinB contains two PKC (protein kinase C) phosphorylations sites, one ATP binding domain and several conserved cysteines and shares 69 % amino acid identity with TorsinA, a related family member. Defects in the gene encoding TorsinB are associated with torsion dystonia, an autosomal dominant neurological disorder that is characterized by debilitating muscle contractions throughout the body.