DACT3 antibody (AA 575-629) (Alexa Fluor 488)

Catalog No. ABIN1393618

Product Details anti-DACT3 Antibody (Alexa Fluor 488)

Target: DACT3 (Dapper, Antagonist of beta-Catenin, Homolog 3 (DACT3))

Binding Specificity: AA 575-629

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DACT3 antibody is conjugated to Alexa Fluor 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DACT3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DACT3

Target: DACT3 (Dapper, Antagonist of beta-Catenin, Homolog 3 (DACT3))

Alternative Name: DACT3 (DACT3 Products)

Synonyms: EG666671 antibody, naa-3 antibody, DAPPER3 antibody, RRR1 antibody, RGD1563892 antibody, dishevelled binding antagonist of beta catenin 3 antibody, dishevelled-binding antagonist of beta-catenin 3 antibody, DACT3 antibody, Dact3 antibody

Background:

Synonyms: Antagonist of beta-catenin Dapper homolog 3, Arginine rich region 1, Arginine rich region 1 protein, Arginine-rich region 1 protein, Dact3 antibody, DACT3_HUMAN, Dapper antagonist of beta catenin 3, Dapper antagonist of beta catenin homolog 3 Xenopus laevis, Dapper homolog 3, Dapper3, Dpr3 antibodyRRR1, RRR1, Thymus expressed gene 3 like.

Background: Dapper3 is a 629 amino acid protein and mammalian homolog of the Xenopus laevis protein dapper. As a member of the dapper family, Dapper3 plays a role in postnatal brain development and contains a C-terminal PDZ-binding motif that facilitates interaction with the PDZ domains of DSH (Dishevelled) family proteins. As the predominant dapper family member found in adult brain, Dapper 3 localizes to hippocampus, Purkinje cell layer and every layer of the dorsal forebrain and cerebral cortex and is also found in the developing murine central nervous system. Dapper3 is also expressed in uterus, ventral somites, branchial arch mesenchyme, aortic sac, aortic arches, limb bud mesenchyme and craniofacical mesenchyme. Mapping to human chromosome 19q13.32, Dapper3 has been identified as a negative regulator of Wnt/beta-catenin signaling in colorectal cancer.