PNMA1 antibody (AA 165-270) (Alexa Fluor 350)

Catalog No. ABIN1394139

Product Details anti-PNMA1 Antibody (Alexa Fluor 350)

Target: PNMA1 (Paraneoplastic Antigen MA1 (PNMA1))

Binding Specificity: AA 165-270

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNMA1 antibody is conjugated to Alexa Fluor 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PNMA1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PNMA1

Target: PNMA1 (Paraneoplastic Antigen MA1 (PNMA1))

Alternative Name: PNMA1 (PNMA1 Products)

Synonyms: PNMA1 antibody, 5730402C15Rik antibody, MA1 antibody, PNMA family member 1 antibody, paraneoplastic antigen MA1 antibody, paraneoplastic Ma antigen 1 antibody, PNMA1 antibody, Pnma1 antibody

Background:

Synonyms: 37 kDa neuronal protein, MA1, Paraneoplastic antigen MA1,

Background: Paraneoplastic neurological disorders (PNDs) are rare syndromes that are caused by, or associated with, an underlying neoplasm. The most common neoplasm among young male patients is testicular cancer, but the leading cause among other patients is lung cancer. Most PNDs are caused by an immune response against onconeural antigens, causing progressive neurological damage. The paraneoplastic antigen MA family contains three known members: MA1, MA2 and MA3. MA1, also designated neuron- and testis-specific protein 1, is a nucleolar protein in normal cells but localizes to the cytoplasm of tumor cells. MA2, also designated onconeuronal antigen MA2, is a nucleolar protein expressed in brain and testis. MA3 is highly expressed in brain and testis and is expressed at low levels in heart, trachea and kidney.