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NSG1 antibody (AA 1-100) (Biotin)

D4S234E Reactivity: Mouse, Monkey WB, ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1398007
  • Target See all NSG1 (D4S234E) Antibodies
    NSG1 (D4S234E) (Neuron-Specific Protein Family Member 1 (D4S234E))
    Binding Specificity
    • 14
    • 10
    • 8
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-100
    Reactivity
    • 30
    • 26
    • 15
    • 12
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Mouse, Monkey
    Host
    • 41
    • 3
    • 1
    Rabbit
    Clonality
    • 42
    • 3
    Polyclonal
    Conjugate
    • 20
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NSG1 antibody is conjugated to Biotin
    Application
    • 45
    • 28
    • 13
    • 13
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Monkey, Mouse
    Predicted Reactivity
    Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human NEEP21
    Isotype
    IgG
    Top Product
    Discover our top product D4S234E Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    NSG1 (D4S234E) (Neuron-Specific Protein Family Member 1 (D4S234E))
    Alternative Name
    NEEP21 (D4S234E Products)
    Synonyms
    D4S234 antibody, D4S234E antibody, NEEP21 antibody, P21 antibody, Neep21 antibody, m234 antibody, p21 antibody, Bsmrb antibody, PEP1 antibody, neuronal vesicle trafficking associated 1 antibody, neuron specific gene family member 1 antibody, NSG1 antibody, Nsg1 antibody
    Background

    Synonyms: neuron-enriched endosomal 21 kDa protein, NSG1_HUMAN.

    Background: NEEP21, also known as Brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (neurotensin receptor 2).

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