SLC9A3 antibody (AA 301-400) (Alexa Fluor 350)

Catalog No. ABIN1399959

Product Details anti-SLC9A3 Antibody (Alexa Fluor 350)

Target: SLC9A3 (Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3))

Binding Specificity: AA 301-400

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC9A3 antibody is conjugated to Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NHE3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SLC9A3

Target: SLC9A3 (Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3))

Alternative Name: hydrogen exchanger 3 (SLC9A3 Products)

Synonyms: SLC9A3 antibody, 9030624O13Rik antibody, AI930210 antibody, NHE-3 antibody, NHE3 antibody, Nhe3 antibody, solute carrier family 9 member A3 antibody, sodium/hydrogen exchanger 3 antibody, Sodium/hydrogen exchanger 3 antibody, putative sodium/hydrogen exchanger 3 (nhe3) antibody, solute carrier family 9 (sodium/hydrogen exchanger), member 3 antibody, SLC9A3 antibody, LOC5570922 antibody, GL50803_102647 antibody, Smp_045680 antibody, Slc9a3 antibody

Background:

Synonyms: Na+/H+ exchanger 3, NHE 3, NHE-3, NHE3, SL9A3_HUMAN, SLC9A 3, Sodium, Slc9a3, Sodium/hydrogen exchanger 3, Sodium/hydrogen exchanger, apical epithelial, Solute carrier family 9 sodium/hydrogen exchanger, isoform 3, Solute carrier family 9 sodium/hydrogen exchanger, member 3, Solute carrier family 9 member 3, MGC126718, MGC126720.

Background: NHE-3 are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+) ions. While NHE-1 is ubiquitously expressed, the NHE isoforms 2-8 have distinct tissue- and cell type-dependent expression and inhibitory characteristics. NHE-3 localizes to the apical membrane of renal proximal tubules where it is responsible for most of the sodium transport and fluid reabsorption. NHE-3 translocates to internal pools where it mediates natriuresis when blood pressure increases abruptly. NHE-3 is also expressed in the stomach and functions to protect the mucosa by secreting protons that diffuse into the mucous cells.

Pathways: Proton Transport