MKRN2 antibody (Alexa Fluor 647)

Catalog No. ABIN1402380

Product Details anti-MKRN2 Antibody (Alexa Fluor 647)

Target: MKRN2 (Makorin Ring Finger Protein 2 (MKRN2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MKRN2 antibody is conjugated to Alexa Fluor 647

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MKRN2/RNF62

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MKRN2

Target: MKRN2 (Makorin Ring Finger Protein 2 (MKRN2))

Alternative Name: RNF62 (MKRN2 Products)

Synonyms: MKRN2 antibody, RNF62 antibody, MGC131105 antibody, mkrn2 antibody, Makorin-2 antibody, hspc070 antibody, wu:fb99a04 antibody, 2610002L04Rik antibody, C81377 antibody, makorin ring finger protein 2 antibody, makorin ring finger protein 2 pseudogene antibody, makorin ring finger protein 2 L homeolog antibody, makorin-2 antibody, makorin, ring finger protein, 2 antibody, MKRN2 antibody, LOC100401355 antibody, mkrn2 antibody, mkrn2.L antibody, Mkrn2 antibody

Background:

Synonyms: HSPC070_ Makorin 2, Makorin ring finger protein 2, Makorin2, Makorin-2 MKRN 2, RING finger protein 62, RNF 62, RNF62, MKRN2_HUMAN, Probable E3 ubiquitin-protein ligase makorin-2, RING finger protein 62.

Background: The Makorins are a family of putative ribonucleoproteins containing two to four C3H zinc fingers that may confer RNA-binding. In addition, they contain a C3HC4 RING zinc finger that allows them to function as E3 ubiquitin ligases. Makorin-2, also known as RNF62, HSPC070 or MKRN2, is a widely expressed, evolutionarily conserved protein with four C3H-type zinc fingers (three at the N-terminus and one at the C-terminus), one RING-type zinc finger and a cysteine and histidine motif similar to that found in Makorin-1. In Xenopus, Makorin-2 functions, via PI 3-kinase/Akt signaling, as a negative regulator of neurogenesis. In humans, Makorin-2 is overexpressed in various cancer cell lines, suggesting a possible role of Makorin-2 in tumor progression. In addition, Makorin-2 is co-expressed with Raf-1 in the same tissues and cell lines.

Gene ID: 23609