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Nibrin antibody (N-Term)
NBN
Reactivity: Human, Mouse, Rat
WB, IF, IHC (p), EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Nibrin Antibody
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Target
See all Nibrin (NBN) Antibodies
Nibrin (NBN)
Binding Specificity
All epitopes for Nibrin antibodies
N-Term
Reactivity
All reactivities for Nibrin antibodies
Human, Mouse, Rat
Host
All hosts for Nibrin antibodies
Rabbit
Clonality
All clonalities for Nibrin antibodies
Polyclonal
Conjugate
All conjugates for Nibrin antibodies
This Nibrin antibody is un-conjugated
Application
All applications for Nibrin antibodies
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Cross-Reactivity (Details)
Species reactivity (tested):Human, Mouse, Rat.
Purification
Affinity chromatography purified via peptide column
Immunogen
16 amino acid synthetic peptide near the amino terminus of Human NIBRIN
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
PBS containing 0.02 % Sodium Azide as preservative
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for Nibrin
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Target
Nibrin (NBN)
Alternative Name
Nibrin (NBN Products )
Synonyms
NBN antibody, AT-V1 antibody, AT-V2 antibody, ATV antibody, NBS antibody, NBS1 antibody, P95 antibody, Nbs1 antibody, im:6911679 antibody, zgc:194152 antibody, nibrin antibody, NBN antibody, nbn antibody, Nbn antibody
Background
NIBRIN (NBN) is a member of the double-strand break repair complex MRE11/RAD50/NBN (MRN) which is involved in DNA double-strand break repair, DNA damage-induced checkpoint activation and plays a critical role in the maintenance of chromosome integrity. NIBRIN contains two modules found in cell cycle checkpoint proteins, a forkhead-associated domain adjacent to a breast cancer carboxy-terminal domain. Mutations in this gene are associated with Nijmegen breakage syndrome and maybe the cause of cancer predisposition and aplastic anemia.Synonyms: Cell cycle regulatory protein p95, NBN, NBS, NBS1, Nijmegen breakage syndrome protein 1, P95
Gene ID
4683
NCBI Accession
NP_002476
Pathways
DNA Damage Repair , Production of Molecular Mediator of Immune Response
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