CHD7 antibody (N-Term)

Catalog No. ABIN1450043

The Rabbit Polyclonal anti-CHD7 antibody is suitable to detect CHD7 in samples from Human and Mouse. It has been validated for WB, IHC (p), IF and EIA.

Quick Overview for CHD7 antibody (N-Term) (ABIN1450043)

Target: CHD7 (Chromodomain Helicase DNA Binding Protein 7 (CHD7))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHD7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-CHD7 Antibody

Binding Specificity: N-Term

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography purified via peptide column

Immunogen: CHD7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CHD7

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CHD7

Target: CHD7 (Chromodomain Helicase DNA Binding Protein 7 (CHD7))

Alternative Name: CHD7

Background: CHD proteins belong to a superfamily of proteins of ATP-dependent chromatin remodeling enzymes that have a unique combination of functional domains, including two N-terminal chromodomains, a SNF2-like ATPase/helicase domain and a DNA-binding domain. These proteins are thought to play a role in early embryonic development by affecting chromatin structure and gene expression. Mutations in one member of this family, CHD7, result in CHARGE syndrome. It colocalizes with embryonic stem (ES) cell master regulators OCT4/POU5F1, SOX2, and NANOG and is thought to modulate ES-specific gene transcription. Together with SOX2, CHD7 has been suggested to also regulate several human disease genes.Synonyms: ATP-dependent helicase CHD7, CHD-7, Chromodomain-helicase-DNA-binding protein 7, KIAA1416

Gene ID: 55636

UniProt: Q9P2D1

Pathways: Sensory Perception of Sound, Chromatin Binding