ITGA4 antibody (pSer1027)

Catalog No. ABIN1450329

The Rabbit Polyclonal anti-ITGA4 antibody (ABIN1450329) specifically detects ITGA4 in IHC, ELISA and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for ITGA4 antibody (pSer1027) (ABIN1450329)

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGA4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-ITGA4 Antibody

Binding Specificity: AA 983-1032, pSer1027

Purpose: Integrin α4 (phospho Ser1027) Antibody

Specificity: Phospho-Integrin α4 (S1027) Polyclonal Antibody detects endogenous levels of Integrin α4 protein only when phosphorylated at S1027.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human Integrin alpha4 around the phosphorylation site of Ser1027. AA range:983-1032

Isotype: IgG

Application Details

Application Notes: IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for ITGA4

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Alternative Name: Integrin Alpha4

Background:

Synonyms: ITGA4; CD49D; Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD antigen CD49d

Background: integrin subunit alpha 4(ITGA4) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],

Gene Name: ITGA4

Protein Name: Integrin alpha-4

Molecular Weight: 115 kDa

Gene ID: 3676

OMIM: 192975

UniProt: P13612

Pathways: Integrin Complex