CRH antibody (AA 104-153)

Catalog No. ABIN1453167

The Rabbit Polyclonal anti-CRH antibody (ABIN1453167) specifically detects CRH in IHC, ELISA and IF. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for CRH antibody (AA 104-153) (ABIN1453167)

Target: CRH (Corticotropin Releasing Hormone (CRH))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRH antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-CRH Antibody

Binding Specificity: AA 104-153

Purpose: CRF Antibody

Specificity: CRF Polyclonal Antibody detects endogenous levels of CRF protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human CRF. AA range:104-153

Isotype: IgG

Application Details

Application Notes: IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for CRH

Target: CRH (Corticotropin Releasing Hormone (CRH))

Alternative Name: CRF

Background:

Synonyms: CRH; Corticoliberin; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone

Background: This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation a

Gene Name: CRH

Protein Name: Corticoliberin

Molecular Weight: 21 kDa

Gene ID: 1392

OMIM: 122560

UniProt: P06850

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Feeding Behaviour