PLAT antibody (AA 38-87)

Catalog No. ABIN1454007

The Rabbit Polyclonal anti-PLAT antibody (ABIN1454007) specifically detects PLAT in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PLAT antibody (AA 38-87) (ABIN1454007)

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAT antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PLAT Antibody

Binding Specificity: AA 38-87

Purpose: tPA Antibody

Specificity: TPA Polyclonal Antibody detects endogenous levels of tPA protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human tPA. AA range:38-87

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PLAT

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Alternative Name: tPA

Background:

Synonyms: PLAT, Tissue-type plasminogen activator, t-PA, t-plasminogen activator, tPA, Alteplase, Reteplase

Background: This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],

Gene Name: PLAT

Protein Name: Tissue-type plasminogen activator

Molecular Weight: 62 kDa

Gene ID: 5327

OMIM: 173370

UniProt: P00750

Pathways: Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome