MPZ antibody

Catalog No. ABIN1513218

Product Details anti-MPZ Antibody

Target: MPZ (Myelin Protein Zero (MPZ))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MPZ antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant protein of human MPZ

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MPZ

Target: MPZ (Myelin Protein Zero (MPZ))

Alternative Name: MPZ (MPZ Products)

Synonyms: CHM antibody, CMT1 antibody, CMT1B antibody, CMT2I antibody, CMT2J antibody, CMT4E antibody, CMTDI3 antibody, CMTDID antibody, DSS antibody, HMSNIB antibody, MPP antibody, P0 antibody, Mpp antibody, P-zero antibody, p0 antibody, sc:d0186 antibody, wu:fc04b11 antibody, wu:fi30g06 antibody, zgc:103775 antibody, myelin protein zero antibody, myelin protein zero S homeolog antibody, MPZ antibody, Mpz antibody, mpz antibody, mpz.S antibody

Background: This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.,MPZ,CHM,CMT1,CMT1B,CMT2I,CMT2J,CMT4E,CMTDI3,CMTDID,DSS,HMSNIB,MPP,P0,Neuroscience,Cell Type Marker,Neurodegenerative Diseases,Neuron marker,Axon marker,MPZ

Molecular Weight: 27 kDa/34 kDa

Gene ID: 4359

UniProt: P25189