Tyrosine Hydroxylase antibody (pSer31)

Catalog No. ABIN1531206

This Rabbit Polyclonal antibody specifically detects Tyrosine Hydroxylase in WB, IHC, IF and ELISA. It exhibits reactivity toward Human, Rat, Mouse and Monkey.

Quick Overview for Tyrosine Hydroxylase antibody (pSer31) (ABIN1531206)

Target: Tyrosine Hydroxylase (TH)

Reactivity: Human, Rat, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tyrosine Hydroxylase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Product Details anti-Tyrosine Hydroxylase Antibody

Binding Specificity: AA 1-50, pSer31

Purpose: TH (phospho Ser62) Antibody

Specificity: Phospho-TH (S62) Polyclonal Antibody detects endogenous levels of TH protein only when phosphorylated at S62.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Tyrosine Hydroxylase around the phosphorylation site of Ser31. AA range:1-50

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Tyrosine Hydroxylase

Target: Tyrosine Hydroxylase (TH)

Alternative Name: Tyrosine Hydroxylase

Background:

Synonyms: TH, TYH, Tyrosine 3-monooxygenase, Tyrosine 3-hydroxylase, TH

Background: The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008],

Gene Name: TH

Protein Name: Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH),Tyrosine Hydrolase

Molecular Weight: 58 kDa

Gene ID: 7054

OMIM: 191290

UniProt: P07101

Pathways: Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour