Lamin A/C antibody (pSer392)

Catalog No. ABIN1531335

Product Details anti-Lamin A/C Antibody

Target: Lamin A/C (LMNA)

Binding Specificity: AA 361-410, pSer392

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Specificity:

Lamin A/C (Phospho-Ser392) Antibody detects endogenous levels of Lamin A/C only when phosphorylated at Ser392.

PhosphorylationH:S392 M:S392 R:S392

Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Lamin A/C around the phosphorylation site of Ser392.

Isotype: IgG

Application Details

Application Notes: WB: 1:500~1:1000 IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:1000

Comment:

Unigene-Number: Hs.594444 (NCBI Gene Symbol: LMNA)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable at -20°C for at least 1 year.

Expiry Date: 12 months

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: Lamin A/C (LMNA Products)

Background:

Synonyms: 70 kDa lamin, LAMA, LMN1, LMNA

NCBI Gene Symbol: LMNA

Molecular Weight: 74 kDa

Gene ID: 4000

OMIM: 115200

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus