TYRO3 antibody (pTyr681, pTyr749)

Catalog No. ABIN1532058

This Rabbit Polyclonal antibody specifically detects TYRO3 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TYRO3 antibody (pTyr681, pTyr749) (ABIN1532058)

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYRO3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TYRO3 Antibody

Binding Specificity: AA 716-765, pTyr681, pTyr749

Purpose: MerTK/Tyro3 (phospho Tyr749/681) Antibody

Specificity: Phospho-MerTK/Tyro3 (Y749/681) Polyclonal Antibody detects endogenous levels of MerTK/Tyro3 protein only when phosphorylated at Y749/681.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MER/SKY around the phosphorylation site of Tyr749/681. AA range:716-765

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for TYRO3

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Alternative Name: MER/SKY

Background:

Synonyms: MERTK, MER, Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, TYRO3, BYK, DTK, RSE, SKY, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kin

Background: This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008],

Gene Name: MERTK/TYRO3

Protein Name: Tyrosine-protein kinase Mer/Tyrosine-protein kinase receptor TYRO3

Molecular Weight: 110 kDa

Gene ID: 10461, 7301

OMIM: 268000

UniProt: Q12866

Pathways: RTK Signaling