SAG antibody (AA 210-290)

Catalog No. ABIN7227368

The Rabbit Polyclonal anti-SAG antibody is suitable to detect SAG in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for SAG antibody (AA 210-290) (ABIN7227368)

Target: SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAG antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SAG Antibody

Binding Specificity: AA 210-290

Purpose: Rabbit Anti-ARRS Polyclonal Antibody

Specificity: The antibody detects endogenous levels of ARRS protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human ARRS protein at AA range: 210-290

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SAG

Target: SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))

Alternative Name: ARRS

Background: S-arrestin, 48 kDa protein, Retinal S-antigen, Rod photoreceptor arrestinSAG (S-Antigen Visual Arrestin) is a Protein Coding gene. Diseases associated with SAG include Oguchi Disease-1 and Retinitis Pigmentosa 47. Among its related pathways are Phototransduction and Visual Cycle in Retinal Rods. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in SAG have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.

Molecular Weight: 44kD

Gene ID: 6295

UniProt: P10523

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling