p107 antibody (AA 335-384)

Catalog No. ABIN1532532

This Rabbit Polyclonal antibody specifically detects p107 in ELISA and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for p107 antibody (AA 335-384) (ABIN1532532)

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This p107 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-p107 Antibody

Binding Specificity: AA 335-384

Purpose: p107 Antibody

Specificity: P107 Polyclonal Antibody detects endogenous levels of p107 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human RBL1. AA range:335-384

Isotype: IgG

Application Details

Application Notes: IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for p107

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Alternative Name: RBL1

Background:

Synonyms: RBL1, Retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, p107, pRb1

Background: The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought thatThe protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms hav

Gene Name: RBL1

Protein Name: Retinoblastoma-like protein 1

Molecular Weight: 120 kDa

Gene ID: 5933

OMIM: 116957

UniProt: P28749

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases