Retinoblastoma Binding Protein 8 antibody (AA 630-679)

Catalog No. ABIN1532780

The Rabbit Polyclonal anti-Retinoblastoma Binding Protein 8 antibody (ABIN1532780) specifically detects Retinoblastoma Binding Protein 8 in ELISA, IHC and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for Retinoblastoma Binding Protein 8 antibody (AA 630-679) (ABIN1532780)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoblastoma Binding Protein 8 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Retinoblastoma Binding Protein 8 Antibody

Binding Specificity: AA 630-679

Purpose: CtIP Antibody

Specificity: CtIP Polyclonal Antibody detects endogenous levels of CtIP protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human RBBP8. AA range:630-679

Isotype: IgG

Application Details

Application Notes: IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Alternative Name: RBBP8

Background:

Synonyms: RBBP8, CTIP, DNA endonuclease RBBP8, CtBP-interacting protein, CtIP, Retinoblastoma-binding protein 8, RBBP-8, Retinoblastoma-interacting protein and myosin-like, RIM, Sporulation in the absence of SPO11 protein 2 homolog, SAE2

Background: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008],

Gene Name: RBBP8

Protein Name: DNA endonuclease RBBP8

Molecular Weight: 101 kDa

Gene ID: 5932

OMIM: 604124

UniProt: Q99708

Pathways: Cell Division Cycle, DNA Damage Repair