BRCA1 antibody (AA 1491-1540)

Catalog No. ABIN1532821

The Rabbit Polyclonal anti-BRCA1 antibody is suitable to detect BRCA1 in samples from Human, Rat and Mouse. It has been validated for WB, ELISA, IHC (p) and IF (p).

Quick Overview for BRCA1 antibody (AA 1491-1540) (ABIN1532821)

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRCA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-BRCA1 Antibody

Binding Specificity: AA 1491-1540

Purpose: BRCA1 Antibody

Specificity: BRCA1 Polyclonal Antibody detects endogenous levels of BRCA1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human BRCA1. AA range:1491-1540

Isotype: IgG

Application Details

Application Notes: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for BRCA1

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Alternative Name: BRCA1

Background:

Synonyms: BRCA1, RNF53, Breast cancer type 1 susceptibility protein, RING finger protein 53

Background: transforming growth factor beta receptor 3(TGFBR3) Homo sapiens This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010],

Gene Name: BRCA1

Protein Name: Breast cancer type 1 susceptibility protein

Molecular Weight: 207 kDa

OMIM: 113705

UniProt: P38398

Pathways: Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus