MAP3K8 antibody (AA 366-415)

Catalog No. ABIN1533088

The Rabbit Polyclonal anti-MAP3K8 antibody (ABIN1533088) specifically detects MAP3K8 in WB, ELISA, IHC (p) and IF (p). The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for MAP3K8 antibody (AA 366-415) (ABIN1533088)

Target: MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-MAP3K8 Antibody

Binding Specificity: AA 366-415

Purpose: Cot Antibody

Specificity: Cot Polyclonal Antibody detects endogenous levels of Cot protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MAP3K8. AA range:366-415

Isotype: IgG

Application Details

Application Notes: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MAP3K8

Target: MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))

Alternative Name: MAP3K8

Background:

Synonyms: MAP3K8, COT, ESTF, Mitogen-activated protein kinase kinase kinase 8, Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2, TPL-2

Background: ectopic P-granules autophagy protein 5 homolog(EPG5) Homo sapiens This gene encodes a large coiled coil domain-containing protein that functions in autophagy during starvation conditions. Mutations in this gene cause Vici syndrome. [provided by RefSeq, Aug 2015],

Gene Name: MAP3K8

Protein Name: Mitogen-activated protein kinase kinase kinase 8

Molecular Weight: 52 kDa

OMIM: 191195

UniProt: P41279

Pathways: PI3K-Akt Signaling, TCR Signaling