LAT antibody (AA 86-135)
Quick Overview for LAT antibody (AA 86-135) (ABIN1533125)
Target
See all LAT AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 86-135
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Purpose
- LAT Antibody
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Specificity
- LAT Polyclonal Antibody detects endogenous levels of LAT protein.
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Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Purity
- > 95 %
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Immunogen
- The antiserum was produced against synthesized peptide derived from human LAT. AA range:86-135
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Isotype
- IgG
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Application Notes
- WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C/1 year
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Expiry Date
- 12 months
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- LAT (Linker For Activation of T Cells (LAT))
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Alternative Name
- LAT
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Background
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Synonyms: LAT, Linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, pp36, p36-38
Background: The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Gene Name: LAT
Protein Name: Linker for activation of T-cells family member 1
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Molecular Weight
- 27 kDa
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Gene ID
- 27040
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OMIM
- 602354
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UniProt
- O43561
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Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
Target
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