MMP2 antibody (AA 611-660)

Catalog No. ABIN1533350

This Rabbit Polyclonal antibody specifically detects MMP2 in WB, IHC, ELISA and IF. It exhibits reactivity toward Human, Rat, Mouse and Monkey.It has been mentioned in 1 publication

Quick Overview for MMP2 antibody (AA 611-660) (ABIN1533350)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivity: Human, Rat, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-MMP2 Antibody

Binding Specificity: AA 611-660

Purpose: MMP-2 Antibody

Specificity: MMP-2 Polyclonal Antibody detects endogenous levels of MMP-2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MMP-2. AA range:611-660

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

References for anti-MMP2 antibody (ABIN1533350)

Matsumoto, Niimi, Kohyama: "Characterization of fibrosis-promoting factors and siRNA-mediated therapies in C-protein-induced experimental autoimmune myocarditis." in: Cellular immunology, Vol. 279, Issue 1, pp. 70-7, (2012) (PubMed).

Target Details for MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Alternative Name: MMP-2

Background:

Synonyms: MMP2, CLG4A, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2, TBE-1

Background: matrix metallopeptidase 2(MMP2) Homo sapiens This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction.The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Win

Gene Name: MMP2

Protein Name: 72 kDa type IV collagenase

Molecular Weight: 73 kDa

Gene ID: 4313

OMIM: 120360

UniProt: P08253

Pathways: Activation of Innate immune Response