MBD3 antibody (AA 221-270)

Catalog No. ABIN1533573

This Rabbit Polyclonal antibody specifically detects MBD3 in WB, ELISA and IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for MBD3 antibody (AA 221-270) (ABIN1533573)

Target: MBD3 (Methyl-CpG Binding Domain Protein 3 (MBD3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBD3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-MBD3 Antibody

Binding Specificity: AA 221-270

Purpose: MBD3 Antibody

Specificity: MBD3 Polyclonal Antibody detects endogenous levels of MBD3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MBD3. AA range:221-270

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MBD3

Target: MBD3 (Methyl-CpG Binding Domain Protein 3 (MBD3))

Alternative Name: MBD3

Background:

Synonyms: MBD3, Methyl-CpG-binding domain protein 3, Methyl-CpG-binding protein MBD3

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],

Gene Name: MBD3

Protein Name: Methyl-CpG-binding domain protein 3

Molecular Weight: 32 kDa

Gene ID: 53615

OMIM: 603573

UniProt: O95983

Pathways: Chromatin Binding