SKIL antibody (AA 616-665)

Catalog No. ABIN1533612

This Rabbit Polyclonal antibody specifically detects SKIL in WB, ELISA, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for SKIL antibody (AA 616-665) (ABIN1533612)

Target: SKIL (SKI-Like Oncogene (SKIL))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SKIL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SKIL Antibody

Binding Specificity: AA 616-665

Purpose: SnoN Antibody

Specificity: SnoN Polyclonal Antibody detects endogenous levels of SnoN protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human SKIL. AA range:616-665

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for SKIL

Target: SKIL (SKI-Like Oncogene (SKIL))

Alternative Name: SKIL

Background:

Synonyms: SKIL, SNO, Ski-like protein, Ski-related oncogene, Ski-related protein

Background: The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Gene Name: SKIL

Protein Name: Ski-like protein

Molecular Weight: 77 kDa

Gene ID: 6498

OMIM: 165340

UniProt: P12757

Pathways: Positive Regulation of Response to DNA Damage Stimulus