STEAP2 antibody (AA 431-480)

Catalog No. ABIN1534012

The Rabbit Polyclonal anti-STEAP2 antibody is suitable to detect STEAP2 in samples from Human and Mouse. It has been validated for IHC, ELISA, WB and IF.

Quick Overview for STEAP2 antibody (AA 431-480) (ABIN1534012)

Target: STEAP2 (STEAP Family Member 2, Metalloreductase (STEAP2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STEAP2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-STEAP2 Antibody

Binding Specificity: AA 431-480

Purpose: STEAP2 Antibody

Specificity: STEAP2 Polyclonal Antibody detects endogenous levels of STEAP2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human STEA2. AA range:431-480

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for STEAP2

Target: STEAP2 (STEAP Family Member 2, Metalloreductase (STEAP2))

Background:

Synonyms: STEAP2, PCANAP1, STAMP1, Metalloreductase STEAP2, Prostate cancer-associated protein 1, Protein up-regulated in metastatic prostate cancer, PUMPCn, Six-transmembrane epithelial antigen of prostate 2, SixTransMembrane protein of prostate 1

Background: STEAP2 metalloreductase(STEAP2) Homo sapiens This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Gene Name: STEAP2

Protein Name: Metalloreductase STEAP2

Molecular Weight: 55 kDa

Gene ID: 261729

OMIM: 605094

UniProt: Q8NFT2

Pathways: Transition Metal Ion Homeostasis