PIKFYVE antibody (AA 71-120)

Catalog No. ABIN1534208

The Rabbit Polyclonal anti-PIKFYVE antibody (ABIN1534208) specifically detects PIKFYVE in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for PIKFYVE antibody (AA 71-120) (ABIN1534208)

Target: PIKFYVE (phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIKFYVE antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PIKFYVE Antibody

Binding Specificity: AA 71-120

Purpose: PIP5KIII Antibody

Specificity: PIP5KIII Polyclonal Antibody detects endogenous levels of PIP5KIII protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human PIP5K. AA range:71-120

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PIKFYVE

Target: PIKFYVE (phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE))

Alternative Name: PIP5K

Background:

Synonyms: PIKFYVE, KIAA0981, PIP5K3, 1-phosphatidylinositol 3-phosphate 5-kinase, Phosphatidylinositol 3-phosphate 5-kinase, FYVE finger-containing phosphoinositide kinase, PIKfyve, Phosphatidylinositol 3-phosphate 5-kinase type III, PIPkin-III, Type

Background: Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring.This gene encodes an enzyme (PIKfyve, also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKf

Gene Name: PIKFYVE

Protein Name: 1-phosphatidylinositol 3-phosphate 5-kinase

Molecular Weight: 237 kDa

Gene ID: 200576

OMIM: 609414

UniProt: Q9Y2I7

Pathways: Inositol Metabolic Process