Apoptosis Inhibitor 5 antibody (AA 421-470)

Catalog No. ABIN1534266

This Rabbit Polyclonal antibody specifically detects Apoptosis Inhibitor 5 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for Apoptosis Inhibitor 5 antibody (AA 421-470) (ABIN1534266)

Target: Apoptosis Inhibitor 5 (API5)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Apoptosis Inhibitor 5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Apoptosis Inhibitor 5 Antibody

Binding Specificity: AA 421-470

Purpose: API5 Antibody

Specificity: API5 Polyclonal Antibody detects endogenous levels of API5 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human API-5. AA range:421-470

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Apoptosis Inhibitor 5

Target: Apoptosis Inhibitor 5 (API5)

Alternative Name: API-5

Background:

Synonyms: API5, MIG8, Apoptosis inhibitor 5, API-5, Antiapoptosis clone 11 protein, AAC-11, Cell migration-inducing gene 8 protein, Fibroblast growth factor 2-interacting factor, FIF, Protein XAGL

Background: This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],

Gene Name: API5

Protein Name: Apoptosis inhibitor 5

Molecular Weight: 57 kDa

Gene ID: 8539

OMIM: 609774

UniProt: Q9BZZ5

Pathways: Growth Factor Binding