SGOL2 antibody (AA 681-730)

Catalog No. ABIN1535371

The Rabbit Polyclonal anti-SGOL2 antibody is suitable to detect SGOL2 in samples from Human, Mouse and Rat. It has been validated for ELISA, IF and IHC.

Quick Overview for SGOL2 antibody (AA 681-730) (ABIN1535371)

Target: SGOL2 (Shugoshin-Like 2 (SGOL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGOL2 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-SGOL2 Antibody

Binding Specificity: AA 681-730

Purpose: Sgo2 Antibody

Specificity: Sgo2 Polyclonal Antibody detects endogenous levels of Sgo2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human SGOL2. AA range:681-730

Isotype: IgG

Application Details

Application Notes: IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for SGOL2

Target: SGOL2 (Shugoshin-Like 2 (SGOL2))

Alternative Name: SGOL2

Background:

Synonyms: SGOL2, Shugoshin-like 2, Shugoshin-2, Sgo2, Tripin

Background: function:During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis (By similarity). May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the shugoshin family.,subcellular location:In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase.,subunit:Directly interacts with PPP2CA.,

Gene Name: SGOL2

Protein Name: Shugoshin-like 2

Molecular Weight: 144 kDa

Gene ID: 151246

OMIM: 612425

UniProt: Q562F6