MC1 Receptor antibody (AA 268-317)

Catalog No. ABIN1535779

The Rabbit Polyclonal anti-MC1 Receptor antibody is suitable to detect MC1 Receptor in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IHC.

Quick Overview for MC1 Receptor antibody (AA 268-317) (ABIN1535779)

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MC1 Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-MC1 Receptor Antibody

Binding Specificity: AA 268-317

Purpose: MC1-R Antibody

Specificity: MC1-R Polyclonal Antibody detects endogenous levels of MC1-R protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MSHR. AA range:268-317

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MC1 Receptor

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Alternative Name: MSHR

Background:

Synonyms: MC1R, MSHR, Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R

Background: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in de

Gene Name: MC1R

Protein Name: Melanocyte-stimulating hormone receptor

Molecular Weight: 34 kDa

Gene ID: 4157

OMIM: 155555

UniProt: Q01726

Pathways: cAMP Metabolic Process, Feeding Behaviour