Cathepsin D antibody (Cleaved-Leu169)

Catalog No. ABIN1536110

The Rabbit Polyclonal anti-Cathepsin D antibody (ABIN1536110) specifically detects Cathepsin D in WB and ELISA. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Cathepsin D antibody (Cleaved-Leu169) (ABIN1536110)

Target: Cathepsin D (CTSD)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin D antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Cathepsin D Antibody

Binding Specificity: AA 150-199, Cleaved-Leu169

Purpose: Cleaved-Cathepsin D HC (L169) Antibody

Specificity: Cleaved-Cathepsin D HC (L169) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin D HC protein resulting from cleavage adjacent to L169.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human CATD. AA range:150-199

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Cathepsin D

Target: Cathepsin D (CTSD)

Alternative Name: CATD

Background:

Synonyms: CTSD; CPSD; Cathepsin D

Background: This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015],

Gene Name: CTSD

Protein Name: Cathepsin D

Molecular Weight: 27 kDa

Gene ID: 1509

OMIM: 116840

UniProt: P07339

Pathways: Peptide Hormone Metabolism