Lamin A/C antibody (AA 401-427)

Catalog No. ABIN1538393

The Rabbit Polyclonal anti-Lamin A/C antibody has been validated for WB. It is suitable to detect Lamin A/C in samples from Human.

Quick Overview for Lamin A/C antibody (AA 401-427) (ABIN1538393)

Target: Lamin A/C (LMNA)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB21443

Product Details anti-Lamin A/C Antibody

Binding Specificity: AA 401-427

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LMNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-427 amino acids from the Central region of human LMNA.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: LMNA Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: LMNA

Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Molecular Weight: 74139

Gene ID: 4000

NCBI Accession: NP_001244303, NP_005563, NP_733821, NP_733822

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus