PFKFB3 antibody

Catalog No. ABIN1680620

Product Details anti-PFKFB3 Antibody

Target: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PFKFB3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human PFKFB3

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PFKFB3

Target: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Alternative Name: PFKFB3 (PFKFB3 Products)

Synonyms: IPFK2 antibody, PFK2 antibody, E330010H22Rik antibody, iPFK-2 antibody, uPFK-2 antibody, PFKFB3 antibody, zgc:73257 antibody, wu:fc31e01 antibody, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 antibody, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 S homeolog antibody, PFKFB3 antibody, Pfkfb3 antibody, pfkfb3.S antibody, pfkfb3 antibody, PTRG_09894 antibody, Tsp_06710 antibody

Background: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016],IPFK2, PFK2, iPFK-2,AMPK Signaling Pathway,Carbohydrate metabolism,Endocrine & Metabolism,Warburg Effect,PFKFB3

Molecular Weight: 60 kDa

Gene ID: 5209

UniProt: Q16875

Pathways: AMPK Signaling, Regulation of Carbohydrate Metabolic Process