MAP2K3 antibody

Catalog No. ABIN1682965

This Rabbit Monoclonal antibody specifically detects MAP2K3 in WB and IF. It exhibits reactivity toward Human.

Quick Overview for MAP2K3 antibody (ABIN1682965)

Target: MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MAP2K3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-MAP2K3 Antibody

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human MEK3

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MAP2K3

Target: MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

Alternative Name: MAP2K3

Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008],MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2,B Cell Receptor Signaling Pathway,Cancer,Cell Biology & Developmental Biology,Cell Intrinsic Innate Immunity Signaling Pathway,Cytoskeleton,Cytoskeleton_Actins,Epigenetics & Nuclear Signaling,ErbB-HER Signaling Pathway,G protein signaling,G protein signaling_G-Protein-Coupled Receptors Signaling to MAPK/Erk,IL-6 Receptor Signaling Pathway,Immunology & Inflammation,Innate Immunity_TLR Signaling,Kinase,Kinase_Serine/threonine kinases,Kinase_Tyrosine kinases,MAPK-P38 Signaling Pathway,Neurodegenerative Diseases,Neuroscience,Signal Transduction,TGF-b-Smad Signaling Pathway,Toll-like Receptor Signaling Pathway,MAP2K3

Molecular Weight: 39 kDa

Gene ID: 5606

UniProt: P46734

Pathways: MAPK Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2