The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013],ERR1, ERRa, ERRalpha, ESRL1, NR3B1,Cancer,Endocrine & Metabolism,Epigenetics & Nuclear Signaling,Mitochondrial metabolism,Mitochondrial metabolism_Mitochondrial Biogenesis,Nuclear Receptor Signaling,Nuclear Receptor Signaling_Nuclear hormone receptors,Nucleotide metabolism,Nucleotide metabolism_Molecular processes,Signal Transduction,Transcription Factors,ESRRA