IDH3B antibody (AA 151-250) (Alexa Fluor 350)

Catalog No. ABIN1693431

Product Details anti-IDH3B Antibody (Alexa Fluor 350)

Target: IDH3B (Isocitrate Dehydrogenase 3 (NAD+) beta (IDH3B))

Binding Specificity: AA 151-250

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IDH3B antibody is conjugated to Alexa Fluor 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IDH3B

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for IDH3B

Target: IDH3B (Isocitrate Dehydrogenase 3 (NAD+) beta (IDH3B))

Alternative Name: Idh3b (IDH3B Products)

Synonyms: H-IDHB antibody, RP46 antibody, C78231 antibody, zgc:86647 antibody, MGC79028 antibody, IDH1 antibody, IDH3 antibody, isocitrate dehydrogenase 3 (NAD(+)) beta antibody, isocitrate dehydrogenase 3 (NAD+) beta antibody, isocitrate dehydrogenase 3 (NAD+) beta S homeolog antibody, IDH3B antibody, Idh3B antibody, Idh3b antibody, idh3b antibody, idh3b.S antibody

Background:

Synonyms: FLJ11043, H-IDHB, IDH3B, IDH3B_HUMAN, Isocitrate dehydrogenase [NAD] subunit beta, Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial, isocitrate dehydrogenase 3, beta subunit, Isocitric dehydrogenase, Isocitric dehydrogenase subunit beta, MGC903, mitochondrial, NAD+-specic ICDH, NAD+-specic ICDH subunit beta, NAD+-specic isocitrate dehydrogenase b subunit, NAD+-specic isocitrate dehydrogenase beta, OTTHUMP00000030023_ OTTHUMP00000030024, RP46.

Background: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].