Fibrinogen antibody (AbBy Fluor® 488)

Catalog No. ABIN1694390

The Rabbit Polyclonal anti-Fibrinogen antibody has been validated for IF (p) and IF (cc). It is suitable to detect Fibrinogen in samples from Cow.

Quick Overview for Fibrinogen antibody (AbBy Fluor® 488) (ABIN1694390)

Target: Fibrinogen

Reactivity: Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Fibrinogen antibody is conjugated to AbBy Fluor® 488

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-Fibrinogen Antibody (AbBy Fluor® 488)

Cross-Reactivity: Cow

Predicted Reactivity: Cow

Purification: Purified by Protein A.

Immunogen: Fibrinogen from bovine plasma

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Fibrinogen

Target: Fibrinogen

Alternative Name: Bovine Fibrinogen

Background:

Synonyms: FGA, FGA protein, FGB, FGG, Fib2, Fibrin alpha chain ,Fibrinogen A alpha polypeptide, Fibrinogen A alpha polypeptide chain, Fibrinogen alpha chain, Fibrinogen B alpha polypeptide, Fibrinogen beta chain, Fibrinogen G alpha polypeptide, Fibrinogen gamma chain, MGC104327, MGC119422, MGC119423, MGC119425, MGC120405.

Background: Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/mL. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.

Gene ID: 522039