Acetyl-CoA Carboxylase beta antibody (pSer220) (Biotin)

Catalog No. ABIN1700093

Product Details anti-Acetyl-CoA Carboxylase beta Antibody (Biotin)

Target: Acetyl-CoA Carboxylase beta (ACACB)

Binding Specificity: pSer220

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Acetyl-CoA Carboxylase beta antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Acetyl Coenzyme A Carboxylase beta around the phosphorylation site of Ser220

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Acetyl-CoA Carboxylase beta

Target: Acetyl-CoA Carboxylase beta (ACACB)

Alternative Name: Acetyl Coenzyme A Carboxylase beta (ACACB Products)

Synonyms: F15C21.2 antibody, F15C21_2 antibody, acetyl-CoA carboxylase 2 antibody, ACC2 antibody, ACCB antibody, HACC275 antibody, Acc2 antibody, AI597064 antibody, AW743042 antibody, Accb antibody, acetyl-CoA carboxylase 2 antibody, acetyl-CoA carboxylase beta antibody, acetyl-Coenzyme A carboxylase beta antibody, ACC2 antibody, ACACB antibody, Acacb antibody

Background:

Synonyms: Acetyl Coenzyme A Carboxylase beta phospho S220, Acetyl Coenzyme A Carboxylase beta phospho Ser2210 p-Acetyl Coenzyme A Carboxylase beta phospho S220, ACACB_HUMAN

Background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

UniProt: O00763

Pathways: AMPK Signaling, Ribonucleoside Biosynthetic Process