Factor 8 beta Chain (AA 1101-1200) antibody (HRP)
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- Target
- Factor 8 beta Chain
- Binding Specificity
- AA 1101-1200
- Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- HRP
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Factor VIII B chain
- Isotype
- IgG
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- Application Notes
-
WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handling Advice
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
-
- Target
- Factor 8 beta Chain
- Synonyms
- AHF antibody, DXS1253E antibody, F8B antibody, F8C antibody, FVIII antibody, HEMA antibody, coagulation factor VIII antibody, F8 antibody
- Background
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Synonyms: coagulation factor VIII, Ahf, Antihemophilic factor, Coagulation factor VIII, Coagulation factor VIII associated protein b, Coagulation factor VIII isoform b, Coagulation factor VIII procoagulent component, Coagulation factor VIIIc, Dna segment on chromosome x unique 1253 expressed sequence, Dxs1253e, F8, F8 protein, F8b, F8c, Factor VIII F8b, FactorVIII, FVIII, Hema coagulation factor VIIIc procoagulent component, Hemophilia a, Hemophilia classic, OTTHUMP00000061446, Procoagulant component, F?-Ag, Factor VIIIa heavy chain, 200 kDa isoform, Factor VIIIa heavy chain, 92 kDa isoform, Factor VIII B chain, AHF, DXS1253E, F8B, F8C, FVIII, HEMA, FA8_HUMAN.
Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].
- Gene ID
- 2157
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