Glycogenin 1 antibody (AA 251-350) (HRP)

Catalog No. ABIN1712067

Product Details anti-Glycogenin 1 Antibody (HRP)

Target: Glycogenin 1 (GYG1)

Binding Specificity: AA 251-350

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glycogenin 1 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Glycogenin 1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Glycogenin 1

Target: Glycogenin 1 (GYG1)

Alternative Name: Glycogenin 1 (GYG1 Products)

Synonyms: GSD15 antibody, GYG antibody, Gyg antibody, gyg antibody, fc13d04 antibody, fi23f07 antibody, gyg1 antibody, wu:fc13d04 antibody, wu:fi23f07 antibody, zgc:55385 antibody, zgc:85619 antibody, glycogenin-1 antibody, MGC79098 antibody, GYG1 antibody, glycogenin 1 antibody, glycogenin 1a antibody, glycogenin 1 S homeolog antibody, GYG1 antibody, Gyg1 antibody, gyg1 antibody, gyg1a antibody, gyg1.S antibody

Background:

Synonyms: Glycogenin, Glycogenin-1, Glycogenin1, GLYG_HUMAN, GN-1, GN1, GYG 1, GYG, GYG1.

Background: Glycogen synthesis is initiated by the autoglucosylation of Glycogenin-1. Specifically, Glycogenin-1 glucosylates itself to begin the synthesis of glycogen in mammalian skeletal muscle. It acts as the primer to which further glucose monomers may be added. All of the Glycogenin-1 Molecules contain at least one glucosyl residue before autoglucosylation begins. The first step of the glycogen synthesis occurs when a glucose molecule from UDP-glucose binds to the hydroxyl group of Tyr 194 on the Glycogenin-1 Molecule. Using its glucosyltransferase activity, Glycogenin-1 adds more glucoses, each one coming from UDP-glucose. The glycosylation process reaches a plateau when five new glucose residues have been added, at which point glycogen synthase (GS) takes over and further elongates the chain. Glycogenin-1 remains covalently attached to the reducing end of the glycogen molecule.

Pathways: Cellular Glucan Metabolic Process