FFAR1 antibody (PE-Cy5)

Catalog No. ABIN1713024

This anti-FFAR1 antibody is a Rabbit Polyclonal antibody detecting FFAR1 in WB. Suitable for Human, Mouse, Rat, Dog and Pig.

Quick Overview for FFAR1 antibody (PE-Cy5) (ABIN1713024)

Target: FFAR1 (Free Fatty Acid Receptor 1 (FFAR1))

Reactivity: Human, Mouse, Rat, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FFAR1 antibody is conjugated to PE-Cy5

Application: Western Blotting (WB)

Product Details anti-FFAR1 Antibody (PE-Cy5)

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GPR40

Isotype: IgG

Application Details

Application Notes: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FFAR1

Target: FFAR1 (Free Fatty Acid Receptor 1 (FFAR1))

Alternative Name: GPR40

Background:

Synonyms: FFA1R, GPR40, GPCR40, Free fatty acid receptor 1, G-protein coupled receptor 40, FFAR1

Background: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis, receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.

Gene ID: 2864

UniProt: O14842

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Carbohydrate Homeostasis