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RAPGEF6 antibody (AA 601-700)

RAPGEF6 Reactivity: Human IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1713889
  • Target See all RAPGEF6 Antibodies
    RAPGEF6 (Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6))
    Binding Specificity
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 601-700
    Reactivity
    • 21
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 19
    • 2
    Rabbit
    Clonality
    • 19
    • 2
    Polyclonal
    Conjugate
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RAPGEF6 antibody is un-conjugated
    Application
    • 12
    • 12
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Predicted Reactivity
    Human,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human RAGEF2
    Isotype
    IgG
    Top Product
    Discover our top product RAPGEF6 Primary Antibody
  • Application Notes
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    RAPGEF6 (Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6))
    Alternative Name
    RAGEF2 (RAPGEF6 Products)
    Synonyms
    KIA001LB antibody, PDZ-GEF2 antibody, PDZGEF2 antibody, RA-GEF-2 antibody, RAGEF2 antibody, A530068K01 antibody, AI844632 antibody, BB085664 antibody, C030018K18Rik antibody, Pdzgef2 antibody, Ragef2 antibody, mKIAA4052 antibody, wu:fa12b02 antibody, RAPGEF6 antibody, Rap guanine nucleotide exchange factor 6 antibody, Rap guanine nucleotide exchange factor (GEF) 6 antibody, RAPGEF6 antibody, Rapgef6 antibody, rapgef6 antibody
    Background

    Synonyms: DKFZp667N084, DKFZp686I15116, KIA001LB, PDZ domain containing guanine nucleotide exchange factor GEF 2, PDZ domain containing guanine nucleotide exchange factor 2, PDZ domain containing guanine nucleotide exchange factor I, PDZ domain-containing guanine nucleotide exchange factor 2, PDZ GEF 2, PDZ GEF2, PDZ-GEF2, PDZGEF 2, PDZGEF2, RA GEF 2, RA GEF2, RA-GEF-2, RAGEF 2, Rap guanine nucleotide exchange factor GEF 6, Rap guanine nucleotide exchange factor 2, Rap guanine nucleotide exchange factor 6, RAPGEF6, RPGF6_HUMAN.

    Background: RAPGEF6 is a guanine nucleotide exchange factor (GEF) that is expressed in a variety of tissues. Localizing to the cytoplasm and translocated to the plasma membrane upon ligand binding, RAPGEF6 contains an N-terminal Ras-GEF domain, a cyclic nucleotide monophosphate-binding domain, a PDZ (PSD-95/DlgA/ZO-1) domain, a Ras-associating (RA) domain and a Ras exchanger motif. RAPGEF6 is closely related to RAPGEF2 and both proteins exhibit GEF activity specific towards Rap 1 and Rap 2. In addition, RAPGEF6 is capable of binding to M-Ras via its RA domain. Due to alternative splicing events, two additional isoforms exist for RAPGEF6, namely PDZ-GEF2A and PDZ-GEF2B.

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