UCMA antibody (AA 21-120)

Catalog No. ABIN1713925

Product Details anti-UCMA Antibody

Target: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Binding Specificity: AA 21-120

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UCMA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UCMA

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for UCMA

Target: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Alternative Name: UCMA (UCMA Products)

Synonyms: BN antibody, GRP-10 antibody, preproGRP antibody, proGRP antibody, grp antibody, GRP2 antibody, ucma antibody, zgc:162317 antibody, C10orf49 antibody, GRP antibody, RGD1308977 antibody, 1110017I16Rik antibody, AW121955 antibody, Grp antibody, GRP1 antibody, zgc:85838 antibody, gastrin releasing peptide antibody, upper zone of growth plate and cartilage matrix associated antibody, upper zone of growth plate and cartilage matrix associated L homeolog antibody, upper zone of growth plate and cartilage matrix associated a antibody, upper zone of growth plate and cartilage matrix associated b antibody, GRP antibody, UCMA antibody, ucma.L antibody, ucmaa antibody, ucma antibody, Ucma antibody, ucmab antibody

Background:

Synonyms: C10orf49, Gla rich protein, Gla-rich protein, Grp, GRP, OTTMUSP00000011599, RP23-272I15.1, UCMA, Ucma-C, UCMA_HUMAN, Unique cartilage matrix associated protein, Unique cartilage matrix-associated protein C-terminal fragment, Upper zone of growth plate and cartilage matrix associated.

Background: UCMA is a 138 amino acid secreted protein that is highly expressed in resting chrondrocytes in developing long bones and is thought to function in the early phase of chrondrocyte differentiation. A furin-like protease processes UCMA into an N-terminal 37 amino acid peptide and a C-terminal 74 amino acid peptide, which is referred to as Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C). Introduction of recombinant Ucma-C interferes with osteogenic differentiation of mesenchymal stem cells, MC3T3-E1 preosteoblasts and primary osteoblasts. This suggests that Ucma may be involved in the negative regulation of osteogenic differentiation of osteochondrogenic precursor cells at the cartilage-bone interface and in peripheral zones of fetal cartilage.

Gene ID: 221044