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Inversin antibody (AA 31-130)

INVS Reactivity: Human, Mouse WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1714386
  • Target See all Inversin (INVS) Antibodies
    Inversin (INVS)
    Binding Specificity
    • 14
    • 5
    • 1
    • 1
    AA 31-130
    Reactivity
    • 22
    • 15
    • 1
    Human, Mouse
    Host
    • 21
    • 1
    Rabbit
    Clonality
    • 22
    Polyclonal
    Conjugate
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Inversin antibody is un-conjugated
    Application
    • 18
    • 12
    • 12
    • 8
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    Cross-Reactivity
    Human, Mouse
    Predicted Reactivity
    Rat,Cow,Sheep,Chimpanzee
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Inversin
    Isotype
    IgG
    Top Product
    Discover our top product INVS Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    Inversin (INVS)
    Alternative Name
    Inversin (INVS Products)
    Synonyms
    invs-a antibody, INVS antibody, MGC140477 antibody, inv antibody, NPH2 antibody, NPHP2 antibody, INV antibody, Nphp2 antibody, RGD1563359 antibody, wu:fe47e11 antibody, inversin S homeolog antibody, inversin antibody, Inversin antibody, invs.S antibody, INVS antibody, Bm1_38710 antibody, PTRG_09181 antibody, EAMY_RS33690 antibody, LOAG_11716 antibody, invs antibody, Invs antibody
    Background

    Synonyms: INV, Inversion of embryo turning homolog, inversion of embryonic turning, INVS, Nephrocystin 2, Nephrocystin-2, Nephrocystin2, nephronophthisis 2 infantile, NPH2, NPHP2, INVS_HUMAN.

    Background: Nephrocystin-2 is a 1,065 amino acid protein that exists as three alternatively spliced isoforms and is essential for establishment of the left-right axis and normal renal development. Localizing to the cytoplasm, cytoskeleton, membrane and nucleus, nephrocystin-2 is expressed during presomite-stage embryos and persists in adulthood, with high levels of expression in liver and kidney. Mice expressing nephrocystin-2 mutations are primarily generated by random insertional mutagenesis and result in the reversal of left/right polarity and cyst formation in the kidneys. Furthermore, altered nephrocystin-2 function reverses nodal and lefty expression, indicating that nephrocystin-2 signaling occurs upstream of these proteins involved in the development of asymmetry.

    Gene ID
    27130
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