DNAJC5 antibody (AA 1-100)

Catalog No. ABIN1715067

Product Details anti-DNAJC5 Antibody

Target: DNAJC5 (DnaJ (Hsp40) Homolog, Subfamily C, Member 5 (DNAJC5))

Binding Specificity: AA 1-100

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNAJC5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CSP

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for DNAJC5

Target: DNAJC5 (DnaJ (Hsp40) Homolog, Subfamily C, Member 5 (DNAJC5))

Alternative Name: CSP (DNAJC5 Products)

Synonyms: CG6395 antibody, CSP antibody, CSP32 antibody, Cys antibody, D-CSP antibody, D.M.CSP antibody, DCSP-1 antibody, Dcsp antibody, Dmel\\CG6395 antibody, MAB ab49 antibody, ab49 antibody, anon-WO02059370.50 antibody, csp antibody, csp29 antibody, csp32 antibody, l(3)03988 antibody, Csp antibody, GB10835 antibody, cb995 antibody, dnajc5 antibody, zgc:92898 antibody, dnajc5a antibody, DNAJC5 antibody, CLN4 antibody, CLN4B antibody, DNAJC5A antibody, NCL antibody, 2610314I24Rik antibody, AU018536 antibody, csp-beta antibody, Cysteine string protein antibody, cysteine string protein antibody, dnaJ homolog subfamily C member 5 antibody, DNAJ/TPR domain-containing protein DNAJC7 family protein antibody, DnaJ (Hsp40) homolog, subfamily C, member 5aa antibody, DnaJ heat shock protein family (Hsp40) member C5 gamma L homeolog antibody, DnaJ heat shock protein family (Hsp40) member C5 gamma antibody, DnaJ (Hsp40) homolog, subfamily C, member 5 antibody, DnaJ heat shock protein family (Hsp40) member C5 antibody, DnaJ heat shock protein family (Hsp40) member C5 S homeolog antibody, Csp antibody, LOC724965 antibody, SJAG_04371 antibody, dnajc5aa antibody, dnajc5g.L antibody, Tsp_06120 antibody, dnajc5g antibody, DNAJC5 antibody, Dnajc5 antibody, dnajc5.S antibody

Background:

Synonyms: CLN 4, CLN4, CLN4B, CSP, cysteine string protein alpha, Cysteine string protein, DJC5, DnaJ Hsp40 homolog subfamily C member 5, DnaJ homolog subfamily C member 5, DNAJC 5, Dnajc5, DNAJC5A, DNJC5_HUMAN, NCL.

Background: Cysteine string proteins (CSPs) are synaptic vesicle-associated, secretory vesicle proteins that are involved in Ca2+-regulated exocytosis of synaptic vesicles and modulation of presynaptic transmembrane calcium fluxes in neuroendocrine and endocrine cell types. CSP contains a J-domain that binds HSP 70/HSC 70 chaperone ATPases and a membrane-targeting, palmitoylated cysteine-rich string region. CSPs may act as molecular chaperones in synapses, and mediate conformational folding of components of the vesicular exocytotic machinery. CSP is involved in the fine tuning of neurotransmission through its interaction with receptor-coupled trimeric GTP binding proteins (G proteins) and N-type Ca2+ channels. Two variants of CSP have been described: CSP1, and the 31 amino acid, C-terminally truncated isoform, CSP2. Subcellular fractionation of insulinoma cells shows CSP1 in granular fractions, while the membrane and cytosol fractions contain predominantly CSP2. The fractions also contain additional proteins, presumably CSP dimers. Furthermore, in various mammalian cell lines (including rat brain) CSP1 expression predominates CSP2 expression.

Gene ID: 80331

Pathways: Synaptic Vesicle Exocytosis