BCL3 antibody

Catalog No. ABIN1721461

This Hamster Monoclonal antibody specifically detects BCL3 in WB, ELISA and FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for BCL3 antibody (ABIN1721461)

Target: BCL3 (B-Cell CLL/lymphoma 3 (BCL3))

Reactivity: Human, Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This BCL3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 150-3-5

Product Details anti-BCL3 Antibody

Specificity: Reacts with human and mouse Bcl-3.

Purification: Purified

Immunogen: Recombinant mouse Bcl-3-6His.

Isotype: IgG1 lambda

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
WB2 μg/mL.

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4

Handling Advice: Dilute in PBS or medium that is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BCL3

Target: BCL3 (B-Cell CLL/lymphoma 3 (BCL3))

Alternative Name: Bcl-3

Background: The gene encoding Bcl-3 was first identified as the gene altered in some cases of chronic B cell lymphocytic leukemia and was later found to belong to the IκB subfamily of inhibitors of NFκB transcription factors. Bcl-3 does not have DNA-binding activity, but it interacts with NFκB1 and NFκB2 which, when bound to DNA, repress gene transcription. Therefore, Bcl-3 may promote gene expression that is repressed by members of the NFκB family. Bcl-3 RNA is highly expressed in spleen and liver with lower levels of expression in heart, skeletal muscle, lung, kidney, and testes.

B-cell lymphoma 3 protein homolog, BCL-3 Gene name: Bcl3

UniProt: Q9Z2F6

Pathways: NF-kappaB Signaling, Maintenance of Protein Location, Protein targeting to Nucleus